CURRICULUM VITAE
JOANNA KATHERINE KRUEGER

Assistant Professor, Department of Chemistry University of North Carolina at Charlotte
9201 University City Blvd. Charlotte, NC 28223-0001 phone: (704) 687-4913 fax: (704) 687-3151 JKKruege@email.uncc.edu


Education

October 1991 Ph. D. in Chemistry. Princeton University
Thesis advisor: Dr. C. E. Schutt, Chemistry Department Thesis title: "Structure Function Studies of the Methylesterase Involved in Bacterial Chemotaxis".

June 1988 M. A. in Chemistry. Princeton University

June 1985 B. A. in Chemistry (A.C.S. certified). Kalamazoo College


Honors and Awards

2001-02 Oak Ridge Associated Universities- Ralph E. Powe Junior Faculty Enhancement Award

1999-02 North Carolina Biotechnology Corporation- Academic Research Initiation Grant Recipient

1994-96 National Research Service Award- A two-year post-doctoral fellowship awarded by the National Heart, Lung and Blood Institute.

1993-94 Cardiology Training Fellowship- National Institutes of Health

1982-85 F. W. and Elsie L. Heyl Scholarship Research

8/99-present: Assistant Professor. University of North Carolina at Charlotte. Chemistry Department
Research Focus: Structural information on biomolecular associations using the techniques of small-angle X-ray and neutron scattering, selected-site mutagenesis and spectroscopy (FTIR, CD, UV-VIS); and visualized through the use of Monte Carlo molecular modeling.

8/95-8/99 Post-doctoral Associate (NIH fellow, 1995-96). Los Alamos National Laboratory Research Advisor: Dr. J. Trewhella, Chemical Science and Technology Division Research: Utilized small-angle X-ray and neutron scattering techniques to study the structures of calcium calmodulin complexed with an enzymatically active myosin light chain kinase as well as other proteins and protein complexes in solution.

7/92-8/95 Post-doctoral Associate (NIH fellow, 1993-95). University of Texas Southwestern Medical Center at Dallas Research Advisor: Dr. J. T. Stull, Physiology Department Research: Used selected-site mutagenesis and kinetic analyses to study the regulatory mechanism for smooth muscle myosin light chain kinase cloned and purified from baculovirus.

7/91-7/92 Research Assistant at U.T. Southwestern Medical Center Supervisor: Dr. R. S. Williams, Departments of Cardiology and Internal Medicine Research: Functional studies involving the use of tissue culture, southern blotting, selected-site mutagenesis and molecular biology to study human myoglobin transcription.


Bibliography (peer-reviewed; last five years only)

Krueger, J. K., Gallagher, S. C., Zhi, G., Geguchadze, R., Persechini, A., Stull, J. and Trewhella, J. (2001, accelerated publication) "Activation of Myosin Light Chain Kinase Requires Translocation of Bound Calmodulin" J. Biol. Chem. 276(7): 4535-4538.

Krueger, J. K., Gallagher, S. C., Wang, A., and Trewhella, J. (2000) "Calmodulin Remains Extended upon Binding to Smooth Muscle Caldesmon: A Combined Small-Angle Scattering and Fourier Transform Infrared Spectroscopy Study." Biochemistry, 39(14): 3979-3987.

Krueger, J., McCrary, B., Wang, A. H.-J., Shriver, J. W., Trewhella, J., and Edmondson, S. P. (1999) "Solution Structure of Sac7d/DNA Complex Studied by Small-Angle X-ray Scattering". Biochemistry 38(32): 10247-10255.

Krueger, J. K., Bishop, N. A., Blumenthal, D. K., Zhi, G., Beckingham, K., Stull, J. and Trewhella, J. (1998) "Calmodulin Binding to Myosin Light Chain Kinase Begins at Substoichiometric Ca2+ Concentrations: A Small-Angle Scattering Study of Binding and Conformational Transitions" Biochemistry 37(51): 17810-17817.

Stull, J. T., Lin, P. J., Krueger, J. K., Trewhella, J., and Zhi, G. (1998) "Myosin Light Chain Kinase: Functional Domains and Structural Motifs". Acta Physiol. Scand. 164: 471-482.

Improta, S., Krueger, J. K., Gautel, M., Atkinson, R., Lefevre, J.-F., Moulton, S., Trewhella, J. and Pastore, A. (1998) "The Assembly of Immunoglobulin-like Modules in Titin: Implications For Muscle Elasticity". J. Mol. Biol. 284(3): 761-777.

Krueger, J. K., Zhi, G., Stull, J.T., and Trewhella, J. (1998) "Neutron Scattering Studies Reveal Further Details of the Ca2+/Calmodulin-Dependent Activation Mechanism of Myosin Light Chain Kinase". Biochemistry 37(40): 13997-14004.

Krueger, J.K., Olah, G. A., Rokop, S., Zhi, G., Stull, J. T. and Trewhella, J. (1997) "Structures of Calmodulin and a Functional Myosin Light Chain Kinase in the Activated Complex: A Neutron Scattering Study." Biochemistry 36: 6017-23.